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PRF in Aesthetic Medicine: Natural Regeneration for Collagen, Skin Quality, and Under-Eye Rejuvenation

February 26, 2026 - By Aster Aesthetics
PRF in Aesthetic Medicine: Natural Regeneration for Collagen, Skin Quality, and Under-Eye Rejuvenation

In aesthetic medicine, there is a growing shift away from simply adding volume and toward improving skin quality at the cellular level. One of the most powerful ways to do this is through Platelet-Rich Fibrin (PRF).

PRF is not filler. It is not toxin. It is regenerative medicine — using your body’s own biology to stimulate collagen, improve elasticity, and support long-term skin health.

At Aster Aesthetics, PRF is approached with intention. Because when it comes to regeneration, technique and planning matter.


What Is PRF?

Platelet-Rich Fibrin (PRF) is derived from a small sample of your own blood. After a gentle centrifuge process, we isolate a concentrated layer rich in:

• Platelets
• Growth factors
• Fibrin matrix
• White blood cells

Unlike older platelet treatments, PRF contains no anticoagulants or additives. The fibrin matrix creates a slow-release system, allowing growth factors to stimulate collagen production gradually over time.

This is cellular signaling — not instant filling.


PRF vs PRP: What’s the Difference?

Many patients are familiar with PRP (Platelet-Rich Plasma), but PRF is considered a more advanced evolution.

Key differences include:

• No anticoagulants added
• Higher fibrin content
• Slower, sustained release of growth factors
• Longer-lasting collagen stimulation

Because PRF releases growth factors over time rather than all at once, results tend to develop more gradually and naturally.

What Does PRF Treat?

PRF is ideal for patients who want improvement in skin quality rather than dramatic volume changes.

Common treatment areas include:

Under-Eyes

PRF is especially popular for under-eye hollows and crepey texture. It can improve thin skin and mild volume loss while stimulating collagen in a delicate area where traditional filler may not always be ideal.

Fine Lines and Texture

By encouraging collagen remodeling, PRF helps soften fine lines and improve skin smoothness.

Acne Scarring

When combined with microneedling, PRF can enhance tissue repair and improve the appearance of acne scars.

Neck and Décolleté

Areas with thinner skin benefit from regenerative stimulation rather than heavy volumizing products.

Hair Restoration

PRF can also support hair follicle stimulation in cases of thinning.


PRF With Microneedling: A Powerful Combination

One of the most effective ways (and one of Aster's favorite treatment combos) is to use PRF is in combination with microneedling.

Microneedling creates controlled micro-injuries that stimulate collagen production. When PRF is applied during treatment, growth factors are delivered directly into the skin, amplifying regenerative signaling.

The result:
• Improved texture
• Enhanced glow
• Stronger skin barrier
• Progressive collagen remodeling

This combination is particularly effective for patients focused on overall skin health and long-term rejuvenation.

What to Expect During Treatment

A PRF appointment typically includes:

• A small blood draw
• Centrifugation to isolate PRF
• Strategic placement based on treatment goals

Treatment time is usually 30–60 minutes.

Because PRF stimulates your body’s natural healing response, results are not immediate. Most patients notice gradual improvement over several weeks as collagen develops. A series of 2–3 treatments is often recommended for optimal results.

Mild swelling or bruising can occur, especially in delicate areas like the under-eyes, but downtime is typically minimal.


Why Technique Matters

PRF is not a “spin and inject” procedure.

Centrifuge settings, processing protocols, placement depth, and treatment planning all influence outcomes. Regenerative medicine requires understanding anatomy, skin quality, and long-term aesthetic goals.

At Aster Aesthetics, PRF is customized — not cookie-cutter. We focus on:

• Individualized placement
• Appropriate treatment intervals
• Combining modalities when indicated
• Educating patients on realistic timelines

Collagen takes time. That is not a flaw — it is the benefit.


Is PRF Right for You?

PRF is ideal if you:

• Prefer natural, biologic treatments
• Want to improve skin quality rather than dramatically change your features
• Are concerned about under-eye hollowing or thin skin
• Want to enhance microneedling results
• Value gradual, authentic-looking improvement

During your consultation, we assess skin thickness, collagen status, and your overall treatment goals to determine whether PRF is appropriate or if another modality may better serve you.


Regeneration Over Camouflage

Modern aesthetics is evolving. Instead of masking concerns, we now have the ability to stimulate the body’s own regenerative capacity.

PRF represents that shift.

Not volume for the sake of volume.
Not overcorrection.
Not artificial change.

Just intentional support of your skin’s ability to rebuild and restore.

If you’re curious whether PRF fits into your long-term skin strategy, schedule a consultation at Aster Aesthetics and let’s create a plan built around collagen, structure, and lasting skin health.