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Microneedling Add-Ons: PRF vs PDGF vs PDRN — Which Is Right for Your Skin?

July 14, 2026 - By Aster Aesthetics
Microneedling Add-Ons: PRF vs PDGF vs PDRN — Which Is Right for Your Skin?

Microneedling is one of the most effective treatments for improving skin texture, fine lines, acne scars, enlarged pores, and overall skin quality. But what many patients don't realize is that the treatment can be customized with advanced regenerative add-ons designed to enhance healing and support even better results.

At Aster Aesthetics, three of our most popular microneedling enhancements are PRF, PDGF, and PDRN. While each supports the skin's natural repair process, they do so in different ways.


Microneedling + PRF

PRF (Platelet-Rich Fibrin) is derived from your own blood and contains a concentrated blend of growth factors that support healing and collagen production.

Because PRF comes directly from your body, many patients appreciate the natural, personalized approach. It is often chosen to support recovery while enhancing overall rejuvenation results.

Microneedling + PDGF

PDGF (Platelet-Derived Growth Factor) delivers a highly concentrated and standardized growth factor signal to the skin.

This advanced regenerative treatment helps support collagen production, tissue repair, and skin renewal. Because it offers consistent dosing and predictable growth factor support, it has become a popular option for patients seeking enhanced rejuvenation and recovery.

Microneedling + PDRN

PDRN (Polydeoxyribonucleotide) is known for its ability to support skin repair, hydration, and barrier function.

Often referred to as a "skin healer," PDRN helps improve skin quality while reducing inflammation and supporting long-term skin health. It is an excellent choice for patients looking to improve overall skin resilience and hydration.


Which Microneedling Add-On Is Best?

The truth is there isn't a single "best" option.

PRF, PDGF, and PDRN each offer unique benefits, and the right choice depends on your skin concerns, goals, and treatment plan.

That's why every microneedling treatment at Aster Aesthetics is customized to the individual. During your consultation, we'll evaluate your skin and recommend the regenerative enhancement that best supports your desired outcome.

Because the best results don't come from following trends—they come from personalized treatment planning.

Ready to take your microneedling results to the next level? Schedule a consultation with Aster Aesthetics in Salem, Oregon to discover which regenerative add-on is right for you.